Comments (3)
Hello,
Can you generate the matrix from your vcf files using SigProfilerMatrixGenerator (https://github.com/AlexandrovLab/SigProfilerMatrixGenerator)?
Thanks
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Your matrices generated with many errors: "Matrices generated for 144 samples with 712919 errors." You are probably using the wrong reference genome. The parameters above specify "reference_genome: GRCh37". Is your data called against GRCh38?
from sigprofilerextractor.
Yes, the data was generated with GRCh38 -- I did rerun again after updating the reference genome and the number of errors dropped to 3. However, I still was not getting an output folder with any results. I upgraded my python to 3.7.3 (see that I ran it initially with 3.6+) after reading through some of the other issues, and things seem to be working correctly, so it seemed the issue was linked to python. Just was strange for me to not encounter an error!
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Related Issues (20)
- install own copy of genome HOT 1
- [Errno 2] No such file or directory HOT 3
- Cosine similarity for each COSMIC signature HOT 1
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- Inquiry Regarding sigProfilerExtractor Resource Requirements HOT 1
- interpretation for SBS 96D HOT 5
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- AttributeError: 'NoneType' object has no attribute 'keys (decomposition.py error) HOT 2
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- Issue with install HOT 2
- ValueError: operands could not be broadcast together with shapes (83,0) (0,0) HOT 3
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- question about the SigProfilerExtractor HOT 1
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- Denovo Signature and Assigning Signature Matching Error HOT 1
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