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Angie Hinrichs's Projects

augur icon augur

Pipeline components for real-time phylodynamic analysis

covid-19-lab-specific-bias-filter icon covid-19-lab-specific-bias-filter

We developed a tool to systematically flag COVID-19 genomes for variants resulting from possible lab specific biases. The program requires a concurrent nextstrain VCF file, nextstrain parsimony file and nextstrain metadata file as input. It outputs two tsv files: one with each flagged snp and the respective reasoning underlying the flag, and another providing more detailed information on each flagged lab.

g-nest icon g-nest

The Gene NEighborhood Scoring Tool (G-NEST) combines genomic location, gene expression, and evolutionary sequence conservation data to score putative gene neighborhoods across all window sizes. Primary author of final code = William F. Martin. Example data files are in the separate repository G-NEST_examples:

hgvslib icon hgvslib

hgvslib provides functions to parse and compare the equivalency of variant strings described according to Human Genome Variation Society (HGVS) syntax.

ncov-ingest icon ncov-ingest

A pipeline that ingests SARS-CoV-2 (i.e. nCoV) data from GISAID and Genbank, transforms it, stores it on S3, and triggers Nextstrain nCoV rebuilds.

nhoodstats icon nhoodstats

science project: find gene clusters for various window sizes, compute avg neighborhood correlation & p-values

pango-designation icon pango-designation

Repository for suggesting new lineages that should be added to the current scheme

pangolearn icon pangolearn

Store of the trained model for pangolin to access.

pangolin icon pangolin

Software package for assigning SARS-CoV-2 genome sequences to global lineages.

pangolin-data icon pangolin-data

Repository for storing latest model, protobuf, designation hash and alias files for pangolin assignments

samtabix icon samtabix

This is a merge of AngieHinrichs/samtools (lh3/samtools patched to allow alternate network lib and not check EOF) and tabix-0.2.6 downloaded from samtools.sourceforge.net. I replaced samtools' bgzf.[ch] with tabix's because tabix's seemed more recent. Had to modify some samtools files to work with updated bgzf.h.

samtools icon samtools

This is Angie Hinrichs' fork of Heng Li's lh3/samtools, which describes itself as "*NOT* the official repository of samtools"; therefore this is even less official. I have applied a patch that adds a wrapper mode to knetfile, so that alternate network libraries (such as UCSC Genome Browser's kent/src/) can be hooked in.

sars-cov-2_sequencing icon sars-cov-2_sequencing

A collection of sequencing protocols and bioinformatic resources for SARS-CoV-2 sequencing.

usher icon usher

Ultrafast Sample Placement on Existing Trees

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