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My bioinformatics research examines the interface between gene regulation and neuroscience. Most of my postdoctoral research was related to developing DMRichR and CpG_Me, which enable the analysis of low-pass whole genome bisulfite sequencing. The following publications demonstrate their potential:

  1. Multi-omic Brain and Behavioral Correlates of Cell-free Fetal DNA Methylation in Macaque Maternal Obesity Models. Nature Communications, 2022. doi: 10.1038/s41467-022-33162-7

  2. Placenta and Fetal Brain Share a Neurodevelopmental Disorder DNA Methylation Profile in a Mouse Model of Prenatal PCB Exposure. Cell Reports, 2022. doi: 10.1016/j.celrep.2022.110442

  3. Placental Methylome Reveals a 22q13.33 Brain Regulatory Gene Locus Associated with Autism. Genome Biology, 2022. doi: 10.1186/s13059-022-02613-1

  4. Cord Blood DNA Methylome in Newborns Later Diagnosed with Autism Spectrum Disorder Reflects Early Dysregulation of Neurodevelopmental and X-linked Genes. Genome Medicine, 2020. doi: 10.1186/s13073-020-00785-8

  5. Low-Pass Whole Genome Bisulfite Sequencing of Neonatal Dried Blood Spots Identifies a Role for RUNX1 in Down Syndrome DNA Methylation Profiles. Human Molecular Genetics, 2020. doi: 10.1093/hmg/ddaa218

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Ben Laufer's Projects

ben-laufer icon ben-laufer

Special repository to add a README.md to GitHub profile

biocthis icon biocthis

Automate package and project setup for Bioconductor packages

cffdna-and-brain-manuscript icon cffdna-and-brain-manuscript

Analyses for the manuscript "Multi-omic Brain and Behavioral Correlates of Cell-free Fetal DNA Methylation in Macaque Maternal Obesity Models."

cgi icon cgi

Takes output from DMRichR and performs statistical testing and visualization for CpG and genic annotation enrichments

chipseeker icon chipseeker

:dart:ChIP peak Annotation, Comparison and Visualization

comethyl icon comethyl

An R package for weighted region comethylation network analysis (Under development).

cpg_me icon cpg_me

A whole genome bisulfite sequencing (WGBS) pipeline for the alignment and QC of DNA methylation that goes from from raw reads (FastQ) to a CpG count matrix (Bismark cytosine reports)

dmrfinder icon dmrfinder

A pipeline to identify differentially-methylated regions from whole-genome bisulfite sequencing data

dmrichr icon dmrichr

A R package and executable for the preprocessing, statistical analysis, and downstream testing and visualization of differentially methylated regions (DMRs) from CpG count matrices (Bismark cytosine reports)

fastq_me icon fastq_me

An example script of how to download WGBS data from SLIMS, check md5sums, merge lanes, and submit a project to CpG_Me

flowsorted.blood.wgbs.blueprint icon flowsorted.blood.wgbs.blueprint

A Bioconductor ExperimentHub data package for flow sorted purified whole blood cell types measured using DNA methylation on WGBS platform from BLUEPRINT

gg4way icon gg4way

Repository for the gg4way BioConductor package

gofuncr icon gofuncr

R-package for GO-enrichment analyses

lola icon lola

Locus Overlap Analysis: Enrichment of Genomic Ranges

low-pass-wgbs-of-ds-ndbs icon low-pass-wgbs-of-ds-ndbs

Analyses for the manuscript "Low-Pass Whole Genome Bisulfite Sequencing of Neonatal Dried Blood Spots Identifies a Role for RUNX1 in Down Syndrome DNA Methylation Profiles"

methylcc icon methylcc

R/BioC package to estimate the cell composition of whole blood in DNA methylation samples in microarray or sequencing platforms

pcb-placenta-and-brain icon pcb-placenta-and-brain

Analyses for the manuscript "Prenatal PCB exposure alters a shared neurodevelopmental DNA methylation profile in mouse placenta and fetal brain".

rna-seq icon rna-seq

RNA-seq alignment and analysis pipeline

scdotplot icon scdotplot

Repository for the scDotPlot BioConductor package

tag-seq icon tag-seq

3’ Tag RNA-seq pipeline (Work in progress)

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