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Kinetic modeling of pathway fluxes for estimating the specific cost in enzymes for sustaining a given flux
Specifically, ECF3 and ECF4 should be made consistent with the definitions in the paper. For example, ECF3 with a CM denominator should not be allowed. ECF4 without allosteric regulation should be enabled.
Add tight linear constraints that are derived from cost approximations, to make the convergence much faster. See the ECM paper supplementary for details.
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