Comments (5)
Hi @wuzhen247, thanks for your interest! In the examples
folder, we provide a tutorial for training a downstream model to predict the fitness of protein variants.
At this time, we do not provide model pre-training in ESM. Internally, we trained these models using the fairseq toolkit. We highly recommend using fairseq for pre-training new models.
Hope that helps! Feel free to reopen the issue if you have any more questions.
from esm.
Hi @wuzhen247, thanks for your interest! In the
examples
folder, we provide a tutorial for training a downstream model to predict the fitness of protein variants.At this time, we do not provide model pre-training in ESM. Internally, we trained these models using the fairseq toolkit. We highly recommend using fairseq for pre-training new models.
Hope that helps! Feel free to reopen the issue if you have any more questions.
Thanks for your suggestions and fast response. I will try them.
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Hi;
Thanks so much for your great work; it is so useful
I have a question regarding the above issue:
In the example you mentioned: "Our embeddings are stored with the file name from fasta header: {index}|{mutation_id}|{effect}.pt"
So, how you did that? I mean how you convert the seq in fasta file to emebedded file ( i mean .pt) ?
Thanks again
Nasser
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Hi @nasserhashemi, this is described under "prerequisites" in the example notebook. Pasting below for your convenience.
You have obtained sequence embeddings for ร-lactamase as described in the README, either by:
runningpython extract.py esm1_t34_670M_UR50S examples/P62593.fasta examples/P62593_reprs/ --repr_layers 34 --include mean
OR
for your convenience we precomputed the embeddings and you can download them from here - see below to download this right here from in this notebook
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Oh, I see, great, Thanks so much for your prompt reply;
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