Currently it is only possible to define a minimum TWR for the whole rocket.
Sometimes (or maybe even most of the time), this is overkill and we only need a high TWR for launch (probably from Kerbin) and lower TWR for later phases (e.g. circularization burn, mun transfer, mun landing). For non-trivial missions this has the potential to significantly reduce engine mass (or increase efficiency) in upper stages (and transitively in lower stages and thereby total rocket mass).
I therefore suggest to allow the configuration of staged TWR constraints (where the staging does not necessarily correlate with the rocket staging). To keep the UI simple a plain text field could be provided where the staged TWR constraints are entered in a special syntax, e.g.:
("TWR >= 2.0 for the first 4000m/s, TWR >= 1.0 for the remainder")
proposed ABNF (like in RFC 4234):
staged_TWR_constraint = *constraint default_constraint
constraint = dV_spec ":" simple_constraint
default_constraint = simple_constraint
dV_spec = FLOAT
simple_constraint = lower_bound
lower_bound = FLOAT
maybe, if you need an upper TWR limit, which I think that is rarely necessary:
simple_constraint = lower_bound ["-" upper_bound]
upper_bound = FLOAT