Comments (6)
Yes, that's what I was thinking. Some of this is there, but not all.
It's unfortunate also that we have lots of separate terms for the same process (nuclear 5' end processing of mRNA ncRNA and cryptic transcripts appear to use the same pathway). I still didn't finish removing the single steps yet. I'll return to that tomorrow. I'll remove the incorrect parent here though because it will cause problems for analyses and annotate lots of gene products to capping inappropriately.
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I think you are right
Cleavage is not capping, so this is incorrect.
I also wonder if it makes sense to have RNA 3'end and 5' end processing; both are maturation, aren't they?
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5' and 3' end processing are both complicated and important pathways with different effects on gene expression. We definitely need them both for mRNA, ncRNA, tRNA.
For the rRNA I'm not so sure that these are separate pathways, especially since the 5' end of one species is sometimes the 3' end of another one and so I agree that just rRNA processing would probably be better here. Some of these terms do seem to be activities describing specific cleavage events. However, I remember when I looked at the annotations they often have a lot of annotations (IMP) as though everything which blocks at each cleavage event is annotated to the cleavage process. I was going to review rRNA processing until the nuclear surveillance pathways are done (I know little about this).
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The problem is that 5' and 3' end processing can lead to either maturation or degradation, and now the ontology is very unclear about this, which seems the most important biological aspect.
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deleted equivalence axiom
'RNA capping' and ('has primary input' some ncRNA)
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git commit -m ‘closes #26208’
(not sure why it didn't close automatically?)
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Related Issues (20)
- Add check to prevent empty literal values HOT 1
- NTR: UDP-glucose biosynthetic process HOT 9
- Missing MetaCyc pathway xrefs (carbohydrate metabolism)
- NTR: [RNA glycosylation] HOT 1
- input/output chemicals on GO:0061624/R-HSA-70350 HOT 2
- 'glycogen biosynthetic process' parents HOT 3
- NTR's ??: additional subtypes of "isotype switching to IgG isotypes (GO:0048291)
- Obsoletion request:GO:0044255, GO:0097384, GO:0044242 cellular lipid metabolic, biosynthetic and catabolic process terms
- Review of glycosaminoglycan metabolic process (GO:0030203) and proteoglycan metabolic process (GO:0006029) branches HOT 1
- Proposed changes to cellular anatomical entity from COB meeting HOT 3
- calcium-activated cation channel activity (GO:0005227) HOT 1
- Textual definition update: GO:0043490 malate-aspartate shuttle
- Obsoletion with replacement: GO:0006948 induction by virus of host cell-cell fusion & GO:0060140 modulation by virus of syncytium formation via plasma membrane fusion
- Response to phosphate/ nutrient homeostasis HOT 8
- go.obo and go-basic.obo have different data-version in snapshot HOT 2
- GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidine should tRNA-specific adenosine-34 deaminase activity be a descendant? HOT 2
- Missing parent: GO:0106340 tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity
- NTR: negative regulation of acetyl-CoA biosynthetic process from pyruvate
- NTR: histone H3K4 deacetylase activity, NAD-dependent HOT 1
- Obsoletion request: GO:0052201 response to symbiont defenses
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