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nuclear avatar nuclear commented on September 26, 2024

Absolutely, thanks for the tag πŸ‘Œ

from go-ontology.

ValWood avatar ValWood commented on September 26, 2024

Author suggestion:
An activity in which a protein, or group of proteins, acts to restrict the size of a fenestration in a membrane or membrane system (i.e. restrict the diameter of a hole in a membrane). An example of this is molecular function is performed by ESCRT-III proteins at the nuclear envelope of fission yeast during anaphase B.

(While we could imagine the ESCRTs being β€œin” the fenestration, it’s certainly possible that they function on the outer or inner nuclear membrane and restrict the membrane by acting there. If possible, I think the language should be intentionally ambiguous as to the structural nature of the grommet, and focus solely on the role)

from go-ontology.

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