Comments (3)
Hi @kaxelsen
Can you comment on this point please?
https://enzyme.expasy.org/EC/1.3.8.5 says:
Name: short-chain 2-methylacyl-CoA dehydrogenase
Reaction: 2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]
There seems to be a mismatch in specificity between the name (short-chain 2-methylacyl) and the reaction (2-methylbutanoyl-CoA) here?
from go-ontology.
There seems to be a mismatch in specificity between the name (short-chain 2-methylacyl) and the reaction (2-methylbutanoyl-CoA) here?
No, it is fine. The chains can be branched as long as they are still aliphatic. Regarding the name, the EC 1.3.8.5 has the highest activity with 2-methylbutanoyl-CoA but also has activity with other short-chain 2-methylacyl-CoA cf pmid:11013134
from go-ontology.
Thanks @kaxelsen. Yes, I see in pmid:11013134 that the enzyme acts on both 2-methylbutyryl-CoA (aka 2-methylbutanoyl-CoA) and isobutyryl-CoA (aka 2-methylpropanoyl-CoA), so it should remain an xref on both GO terms mentioned above.
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from go-ontology.