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ValWood avatar ValWood commented on September 26, 2024

Also consider:
GABA (gamma-aminobutyrate) shunt
as a primary name?
(check usage)

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ValWood avatar ValWood commented on September 26, 2024

GO:0009450 | gamma-aminobutyric acid catabolic process
appears to be a pathway intermediate here describing the second step:
Screenshot 2023-12-21 at 12 45 23

I blocked GO:0009450 @pombase (includes some PAINT annotation)

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ValWood avatar ValWood commented on September 26, 2024

Pombase used the more specific
GO:0034386 4-aminobutyrate:2-oxoglutarate transaminase activity
instead of
GO:0003867 4-aminobutyrate transaminase activity
but this is 2.6.1.19

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deustp01 avatar deustp01 commented on September 26, 2024

There is a tangential but possibly important question here: can processes have other processes as parts? This relationship seems plausible. The work to identify cassettes in signaling processes fits well with this view: a ligand binding and receptor activation sequence feeds into a MAP kinase cascade feeds into modification of gene expression.

And there's the worked-out example of kinds of glycolysis. GO:0061620 "glycolytic process through glucose-6-phosphate", defined as the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP. This process has children GO:0061621 canonical glycolysis (the glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP), GO:0061622 glycolytic process through glucose-1-phosphate (The chemical reactions and pathways through a glucose-1-phosphate intermediate that result in the catabolism of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP), and GO:0061633 transport-coupled glycolytic process through glucose-6-phosphate (the chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, in which the glucose is converted to glucose-6-phosphate intermediate coupled to transmembrane transport) @ukemi

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ValWood avatar ValWood commented on September 26, 2024

A more fundamental problem, Pombe doesn't appear to have GAD1 so I don't know how we get from
glutamate to 4-aminobutonoate. I will need to extend further for sure.

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ValWood avatar ValWood commented on September 26, 2024

Closing, I don't think this is a blocker, and I know little about the pathway

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