NTR: snoRNA and snRNA 2,2,7-trimethylguanosine (TMG) cap formation about go-ontology

[ValWood]

These are the first 3 steps:
#26939
but cannot be used currently for snRNA and snoRNA

[ValWood]

I have found a term "snRNA capping" but it is incorrectly/vaguely defined as

The addition of a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA). Capping 7SK RNA stabilizes it.

(i.e gene product specific, this only applies to a single eukaryote specific snRNA)

@pgaudet should I broaden this term to match the label? is that allowed?

[pgaudet]

should I broaden this term to match the label? is that allowed?

Yes, this is fine

[ValWood]

1. GO:1990273 repurposed to snRNA 2,2,7-trimethylguanosine (TMG) capping

Exact synonym snRNA capping

DEF The sequence of enzymatic reactions by which a 2,2,7-trimethylguanosine cap structure is added to the 5' end of an snRNA.

GLOSS The snRNA capping includes the formation of 7-methyl-G caps found on all RNA polymerase II transcripts, followed by hypermethylation at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. Note that the pol III transcribed U6 snRNA is also TMG capped.

2. GO:1990273 PARENT + GO:0036260 RNAcapping

GO:NEW snoRNA 2,2,7-trimethylguanosine (TMG)capping

Exact synonym snoRNA capping

DEF The sequence of enzymatic reactions by which a 2,2,7-trimethylguanosine cap structure is added to the 5' end of an snoRNA.

GLOSS The snoRNA capping includes the formation of 7-methyl-G caps found on all RNA polymerase II transcripts, followed by hypermethylation at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. Note that the pol III transcribed snoRNAs are also TMG capped.

PARENTS 'sno(s)RNA processing' +GO:0036260 RNA capping

[ValWood]

[Term]
id: GO:0180031
name: snoRNA 2,2,7-trimethylguanosine (TMG) capping
namespace: biological_process
def: "The sequence of enzymatic reactions by which a 2,2,7-trimethylguanosine cap structure is added to the 5' end of an snoRNA. The snoRNA capping includes the formation of 7-methyl-G caps found on all RNA polymerase II transcripts, followed by hypermethylation at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. Note that the pol III transcribed snoRNAs are also TMG capped." [GOC:vw, PMID:15590684]
synonym: "snoRNA 2,2,7-trimethylguanosine (TMG) cap formation" EXACT []
synonym: "snoRNA capping" EXACT []
is_a: GO:0036260 ! RNA capping
is_a: GO:0043144 ! sno(s)RNA processing
intersection_of: GO:0000966 ! RNA 5'-end processing
intersection_of: has_primary_input SO:0000275 ! snoRNA
property_value: term_tracker_item "#26940" xsd:anyURI
created_by: vw
creation_date: 2024-02-07T13:55:54Z