EC:1.14.14.178 steroid 22S-hydroxylase about go-ontology

[pgaudet]

Hi @raymond91125

I simplified the reaction to "Catalysis of the reaction: a C28-steroid + O2 + reduced NADPH--hemoprotein reductase = a (22S)-22-hydroxy C28-steroid + H+ + H2O + oxidized NADPH--hemoprotein reductase. Also catalyzes the C-22 hydroxylation of a variety of C27 and C29 steroids."

Also, I made the EC skos:exactMatch, since with @sjm41 we came to the conclusion that we cannot assume the relation between GO terms and EC, so it's better to state when we know it.

Thanks, Pascale

[raymond91125]

+[Term]
+id: GO:0160191
+name: steroid 22S-hydroxylase activity
+namespace: molecular_function
+def: "Catalysis of the reaction: a C27-steroid + O2 + reduced NADPH--hemoprotein reductase = a (22S)-22-hydroxy C27-steroid + H+ + H2O + oxidized NADPH--hemoprotein reductase, a C28-steroid + O2 + reduced NADPH--hemoprotein reductase = a (22S)-22-hydroxy C28-steroid + H+ + H2O + oxidized NADPH--hemoprotein reductase, or a C29-steroid + O2 + reduced NADPH--hemoprotein reductase = a (22S)-22-hydroxy C29-steroid + H+ + H2O + oxidized NADPH--hemoprotein reductase." [EC:1.14.14.178]
+synonym: "steroid C-22 hydroxylase activity" EXACT [EC:1.14.14.178]
+xref: EC:1.14.14.178
+xref: MetaCyc:RXN-22825 {source="skos:narrowMatch"}
+xref: MetaCyc:RXN-22826 {source="skos:narrowMatch"}
+xref: MetaCyc:RXN-22827 {source="skos:narrowMatch"}
+xref: RHEA:70059 {source="skos:narrowMatch"}
+xref: RHEA:70063 {source="skos:narrowMatch"}
+xref: RHEA:70067 {source="skos:narrowMatch"}
+is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
+property_value: term_tracker_item "#28221" xsd:anyURI
+created_by: rynl
+creation_date: 2024-06-27T00:40:39Z