Comments (7)
In reality this enzyme appears to have 2 activities, i) cleaving the signal peptide, and ii) transferring the GPI anchor onto the protein
I din't know any actual data here, but there is the textbook possibility that this is a transpeptidation in which the cleavage and transfer are accomplished in a single reaction.
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That appears the case
see figure 3
https://www.researchgate.net/publication/6446252_Thematic_review_series_Lipid_Posttranslational_Modifications_GPI_anchoring_of_protein_in_yeast_and_mammalian_cells_or_how_we_learned_to_stop_worrying_and_love_glycophospholipids/figures?lo=1
In this situation I guess we add the missing parent
GO:0008483 transaminase activity to the MF GO:0003923 GPI-anchor transamidase activity
and keep the cysteine-type endopeptidase.
from go-ontology.
whoops that is GO:0008483 transaminase activity we don't have " transamidase activity"
facilitates the transfer of an amide group (-CONH2) from one molecule to another.
General reaction:
R-CONH-R’ + R”-NH2 → R-CO-NH-R” + R’-NH2 R-CONH-R’+R”-NH2→R-CO-NH-R”+R’-NH2
from go-ontology.
@pgaudet we do not have " transamidase activity" so I will add the parent
GO:0016769 transferase activity, transferring nitrogenous groups
I
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another bit of weirdness.
This has an additional redundant parent in Protege?
"catalytic activity acting on a protein"
Why is that?
from go-ontology.
another bit of weirdness.
This has an additional redundant parent in Protege?
"catalytic activity acting on a protein"
What's wrong with this?
from go-ontology.
I wasn't sure why it has the instantiated subclass of a parent term?
"catalytic activity, acting on a protein"
But it doesn't show in QuickGO as a relationship
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Related Issues (20)
- GO:0070330 aromatase activity: fix xrefs HOT 1
- Updates for terms GO:0030283, GO:0047045, GO:0047035 and GO:0035410
- Remove the Parentage "GO:0032993 protein-DNA complex from chromatin and kinetochore HOT 2
- 4-hydroxy-2-oxoglutarate aldolase activity terms HOT 1
- Merge endo-1,3(4)-beta-glucanase activity (EC:3.2.1.6) terms HOT 1
- NTR: L-lactate dehydrogenase inhibitor activity
- NTR: regulation term GO:0031122 cytoplasmic microtubule organization
- dextransucrase activity (GO:0047849) etc HOT 1
- 1,3-beta-D-glucan synthase complex (GO:0000148) superclass
- dolichol-linked oligosaccharide biosynthetic process HOT 2
- Check cross references to UM-BBD enzymes
- Adding missing catalytic activity term xrefs based on def xref
- NTR: [histone H3-K27 methyltransferase activator activity]
- Textual definition update: GO_0035098 - ESC/E(Z) complex HOT 1
- Merge hydroxyproline O-arbinofuranose transferase terms
- Missing MetaCyc Xref for GO:0052811
- Missing parent: propose "GONEW ferric iron reductase" HOT 4
- Textual definition update: GO:0052811 GO:0000285 GO:0035005 GO:0016308 GO:0046934 GO:0016309 GO:0016303 GO:0004430 GO:0052810
- lipase activity edits
- Catalytic activity terms with no cross references
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