Comments (6)
11.03.22
- suspended 1.7907 g (2.96 mmol) KBS9 in methanol (35 mL)
- added NaOH (2.5 M, 100 mL)
- left stirring from 9.45 am
- added boc anhydride (1.5499 g, 7.10 mmol, 2.4 equiv) at 11.30 am
from usyd_phd_eln.
12.03.22
- TLC'd and saw reaction was not complete
- added 1.8044 g (8.27 mmol) propargyl bromide at 5 pm
from usyd_phd_eln.
15.03.22
- TLC'd at 10 am
- added 555 mg (2.54 mmol, 0.85 equiv.) boc anhydride at 12.45
from usyd_phd_eln.
16.03.22
- TLC'd again and reaction was not entirely complete. Decided to work up anyway
- removed methanol via rotary evaporation
from usyd_phd_eln.
18.03.22
- product showed evidence of impurities (overweight, possible water peak on NMR)
- put in dessicator (CaCl2 under vacuum)
from usyd_phd_eln.
NMR
H NMR (300 MHz, CDCl3): δ 1.45 (s, 18 H), 1.63 (m, 4H), 2.16 (s, 2H), 2.52 (t, 4H), 2.63 (m, 4H), 3.24-3.39 (br m, 12H)
Mass Spec
LRMS
477.3 [M+H], 499.3 [M+Na]
from usyd_phd_eln.
Related Issues (20)
- KBS49-2 - Mitsunobu reaction with KBS28 and KBS45 HOT 17
- KBS48-2 - Mitsunobu reaction with KBS28 and KBS43 HOT 15
- KBS44, 52, 53 (Nosyl deprotection) - master page HOT 4
- KBS50-1 - Nosyl protection of bis(3-aminopropyl)amine HOT 13
- KBS44-2 - Nosyl deprotection of KBS49 HOT 12
- KBS50-2 - Nosyl protection of bis(3-aminopropyl)amine HOT 9
- KBS53-1 - Nosyl deprotection of KBS48 HOT 13
- KBS52-1 - Nosyl deprotection of KBS51 HOT 7
- KBS51-1 - Mitsunobu reaction with KBS28 and KBS50 HOT 10
- KBS53-2 - Nosyl deprotection of KBS48 HOT 11
- KBS48 (pooled) - purification HOT 3
- KBS52-2 - Nosyl deprotection of KBS51 HOT 2
- KBS51-2 - Mitsunobu reaction with KBS28 and KBS50 HOT 5
- KBS22-2 - Linear click coupling of bis-propargyl diaminohexane and azidoadamantane HOT 6
- Carlota's compounds - for purification HOT 2
- KBS22-3 - Linear click coupling of bis-propargyl diaminohexane and azidoadamantane HOT 8
- KBS52-3 - Nosyl deprotection of KBS51 HOT 16
- 2024_BG_A_1 - Formation of benzoyl thioureas HOT 2
- 2024_BG_B_1 - Hydrolysis of benzoyl thioureas HOT 2
- SAR - for future aminothiazoles
Recommend Projects
-
React
A declarative, efficient, and flexible JavaScript library for building user interfaces.
-
Vue.js
🖖 Vue.js is a progressive, incrementally-adoptable JavaScript framework for building UI on the web.
-
Typescript
TypeScript is a superset of JavaScript that compiles to clean JavaScript output.
-
TensorFlow
An Open Source Machine Learning Framework for Everyone
-
Django
The Web framework for perfectionists with deadlines.
-
Laravel
A PHP framework for web artisans
-
D3
Bring data to life with SVG, Canvas and HTML. 📊📈🎉
-
Recommend Topics
-
javascript
JavaScript (JS) is a lightweight interpreted programming language with first-class functions.
-
web
Some thing interesting about web. New door for the world.
-
server
A server is a program made to process requests and deliver data to clients.
-
Machine learning
Machine learning is a way of modeling and interpreting data that allows a piece of software to respond intelligently.
-
Visualization
Some thing interesting about visualization, use data art
-
Game
Some thing interesting about game, make everyone happy.
Recommend Org
-
Facebook
We are working to build community through open source technology. NB: members must have two-factor auth.
-
Microsoft
Open source projects and samples from Microsoft.
-
Google
Google ❤️ Open Source for everyone.
-
Alibaba
Alibaba Open Source for everyone
-
D3
Data-Driven Documents codes.
-
Tencent
China tencent open source team.
from usyd_phd_eln.