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Excluding paralogs about trifusion HOT 3 CLOSED

jmbraverman avatar jmbraverman commented on August 25, 2024
Excluding paralogs

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Comments (3)

ODiogoSilva avatar ODiogoSilva commented on August 25, 2024

Hi @jmbraverman , thank you for your feedback. There are a couple of ways you can filter out paralogs and keep only single-copy orthologs.

When performing an ortholog search you can change the "Maximum number of gene copies" to 1 in order to keep only single copy genes http://trifusion.readthedocs.io/en/latest/orto_search.html#orthology-search-options.

If you have already performed the search, you can load the resulting group files in the Explore section, apply the filter mentioned above and export the filtered orthologs as protein/DNA http://trifusion.readthedocs.io/en/latest/orto_explore.html#change-the-orthology-filters.

Let me know if you run into any issue!

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jmbraverman avatar jmbraverman commented on August 25, 2024

Thank you very much for replying. I actually had been using that filter. But I double-checked it by redoing some of my analysis today. I ran into a few more questions and may follow-up.

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ODiogoSilva avatar ODiogoSilva commented on August 25, 2024

Fixed via #295

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