ExPheWas seems awesome to me!

The GitHub, however, feels less helpful than it could.

I suggest to add a README with links to the pre-print (and accepted manuscript in the future) and browser, such as the text below. That would help me and others to find the other parts.

Sure I can make a Pull Request to the dev branch if asked :-)

Cheers, Richel

ExPheWas

ExPheWas is [what it is] and can be found at https://exphewas.statgen.org.

Citation

Legault, Marc-André, Louis-Philippe Lemieux Perreault, and Marie-Pierre Dubé. "ExPheWas: a browser for gene-based pheWAS associations." medRxiv (2021).

Manuscript can be found here

I was wondering if it is possible to download all the cis MR results for all genes, all exposures and all outcomes. Thanks.

Dear Team,

I am wondering is there any timeline to implement: Instrumental variable (eQTL and pQTL) -> mRNA-expression, protein level -> outcome (disease/phecode).

Thanks.

Shicheng

• Set default variance explained at 95%
• Expose MAF threshold as parameter
• Allow sex-stratified PCA
• Select only bi-allelic SNPs
• Save CSV as gzip compressed by default
• Allow imputation quality filtering (?)