Comments (10)
Hi Philip,
You may not remember opening this issue. But I surely have not forgotten. It finally happened. From now on, you can cite our publication. I will update the README and user manual shortly. What a pleasure to finally close this issue ...
Regards,
Sebastian
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Dear Philip,
I'm still working on a method paper about Arriba. Until then, please refer to Arriba in your methods section as follows (or similar):
We used Arriba (https://github.com/suhrig/arriba/) to detect gene fusions from RNA-Seq data.
Regards,
Sebastian
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NAs introduced by coercion
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Congrats Sebastian!
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We compared the performance of Arriba v1.0.0 against six commonly used fusion detection algorithms ...
But, what about version 2.0.0? It must be even more accurate than the competitors. Also, would like to see evaluation for total RNA.
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congrats on the paper!
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But, what about version 2.0.0?
Haha, you are absolutely right. The review took so long (a lot due to Corona lockdown) that it is almost time for a follow-up publication. It took a whopping 1.5 years from finishing the manuscript to publication ...
Also, would like to see evaluation for total RNA.
Good point. I would be interested as well. I'm sure among the thousands of samples that I have run Arriba on, there are some total RNA ones. I just never looked at them specifically.
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Hi Sebastian,
Can you add the paper at the bottom of your README.md and/or somewhere on the RTD cite? To find it I had to go in here. Do you have a Twitter account or anything I can RT an announcement about it?
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Perhaps it will be added once there is volume, issue and page numbers available. Currently, it's Advance Online Article.
Total RNA has many more false positives with the intronic, untailed, anti-sense Alu repeats, as shown in #92 which are discarded by sample preparation protocols that retain only poly-A tails. I can send adapter-trimmed FASTQs for algorithm testing, if needed.
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I am currently finalizing version 2.1.0. I will update the README / manual when I push the new release.
@DarioS: Thanks for the offer of sending FastQs. I might come back to you offer. I think I even have some samples with multiple libraries (polyA & total) such that I could make direct comparisons. Anyhow, we should continue the discussion in the appropriate issue (#92).
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Related Issues (20)
- Gene annotation HOT 1
- Different gene fusions from the same alignments HOT 2
- On the classification of the results about the fusion_transcript HOT 4
- Failed to read BGZF block data at offset HOT 5
- How to calculate fusion gene expression? HOT 8
- Aligned.out.bam file empty HOT 13
- General question about breakpoints HOT 1
- Low number of structural variants HOT 4
- e-value threshold HOT 2
- possibly incorrect determination of the frame HOT 5
- EOF marker is absent. The input may be truncated HOT 1
- Error downloading reference data HOT 3
- How breakpoints should be interpreted on doubled 5' transcript end gene-fusions? HOT 2
- Segmentation fault on Re-aligning chimeric reads to filter fusions HOT 2
- Split reads evidence for EWSR1-NR4A3 fusion missing in sample.arriba.fusions.discarded.tsv HOT 2
- Validating New Versions HOT 4
- How to get the position of the fused gene on the chromosome? HOT 3
- Giving known fusions list does not recover the fusions I want HOT 4
- request for simulation dataset mentioned in the paper HOT 2
- intergenic breakpoints reported without distances to genes HOT 1
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