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An updated version of meta-analysis software Raremetal

Makefile 0.19% Fortran 13.23% C 1.89% C++ 82.61% Shell 0.18% CMake 1.68% Python 0.08% JavaScript 0.07% CSS 0.04% Perl 0.03%

raremetal2's Introduction

Raremetal: A tool for rare variants meta-analyse
	(c) 2012-2017 Sai Chen, Shuang Feng, Dajiang Liu, Goncalo Abecasiss

For more info, please see wiki page
http://genome.sph.umich.edu/wiki/RAREMETAL

Raremetal2 is an updated version of the meta-analysis software Raremetal
It is 30% faster than the original version and takes less memory
Compatiable with old Raremetalworker or rvtest generated summary files

This is still a beta version. Single-variant meta-analysis looks good on T2D and MGI data,  but needs more optimizations on group test.

New features:
1. new method for unbalanced studies. To toggle that, please specify --useExact
2. multi-allelic site meta-analysis enabled. However, if you have Raremetalworker or rvtest covariance files from previous versions, multi-allelic site meta-analysis won't work well in group test because these old covariance files do not record alleles for each sites.
3. missing data in conditional analysis

raremetal2's People

Contributors

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James Cloos avatar Andy Boughton avatar  avatar

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