asancpt / ncarcdisc

:weary: OBSOLETE! R package: Noncompartmental Analysis of Pharmacokinetic Data for CDISC Standardized Parameters

ncarcdisc: Noncompartmental Analysis of Pharmacokinetic Data for CDISC Standardized Parameters

ncarcdisc R package (Branch of NonCompart v0.2.6 R package)

Overview

Description: Conduct a noncompartmental analysis as closely as possible to the most widely used commercial software for pharmacokinetic analysis, i.e. 'Phoenix(R) WinNonlin(R)' https://www.certara.com/software/pkpd-modeling-and-simulation/phoenix-winnonlin/.

Some features include:

1. Use CDISC SDTM PP domain terms.
2. Automatic slope selection with the same criterion of WinNonlin(R)
3. Support both 'linear-up linear-down' and 'linear-up log-down' method
4. Calculate partial(interval) AUC with 'linear' or 'log' interpolation method
5. Perform a noncompartmental analysis of CDISC standardized pharmacokinetic dataset (.XPT)

For more details on noncompartmental analysis, see the reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107)

Acknowledgement: Author thanks for the careful review and valuable input of Dr. Jee Eun Lee.

Installation

CRAN

# get stable version
install.packages('ncar')

Github

# get development version
install.packages('devtools')
devtools::install_github('asancpt/ncar')

Contact

• ncarcdisc Package developer: Kyun-Seop Bae [email protected], Sungpil Han [email protected]
• Copyright: 2017, Kyun-Seop Bae
• License: GPL-3

ncarcdisc's Issues

Today's issues

There were some suggestions.

• Time zone needs to be universal. RESOLVED asancpt/ncar@0aa2dfc
• Unit-conversion method using measurements package should be replaced for compatibility to CDISC.
• Multiple dose NCA
• Convert PC to PP and check accuracy. Definitely I can adopt this functionality from Online NonCompart Shiny app. https://github.com/asancpt/noncompart/blob/master/server.R RESOLVED asancpt/ncar@f8f95ac

I will check the NonCompart package update, and review the updated code and work on these issues later .