Install virtualenv if you necessary
pip install virtualenv
virtualenv venv
source venv/bin/activate
pip install Flask
export FLASK_APP=app
flask run
brew install ngrok/ngrok/ngrok
export PATH=$PATH:/path/to/ngrok/directory
ngrok http 5000
You can do it by running the link in your browser
https://api.telegram.org/bot<BOT_TOKEN>/setWebhook?url=<HTTPS_URL_FROM_NGROK>