decontaminating pancreatic dataset about soupx

[constantAmateur]

It looks like you're just using the top 50 genes as expressed in the soup to determine the contamination fraction. You should not be doing this, doing so will over-estimate the contamination fraction (potentially by a lot, I doubt your contamination is really as high as 37%). The correct thing to do is to pick genes that you know should not be expressed in a set of cells. I'm not an expect in your context, but something like Insulin in Acinar cells, that you know shouldn't be there. See the vignette for an example.

Failing that, you're better off setting the contamination fraction to something reasonable (like 10%) and proceeding with that.