An R package to find the gaps in metabolic networks, and fill it from the stoichiometric reactions of a reference metabolic reconstruction using a weighting function. Also include the option to download all the set of gene-associated stoichiometric reactions for a specific organism from the KEGG database.
Hi, I wanted to try this method of gapfilling but am encountering persistent errors retrieving references:
library('g2f')
all <- getReference(organism = "all",sep = ";")
OK
Downloading reactions ... Error in curl::curl_fetch_memory(url, handle = handle) :
OpenSSL SSL_read: error:0A000126:SSL routines::unexpected eof while reading, errno 0
eco <- getReference(organism = "eco",sep = ";")
Validating selected organism ... Error in download.file("rest.kegg.jp/list/organism", paste0(kegg_download, :
download from 'rest.kegg.jp/list/organism' failed
In addition: Warning message:
In download.file("rest.kegg.jp/list/organism", paste0(kegg_download, :
URL 'https://rest.kegg.jp/list/organism': status was 'Failure when receiving data from the peer'
I am on ubuntu and using the latest openssl (3.0.2) and nginx (1.22)
As there is no help file for this library, is there a manual way to insert reference reactions or can this issue be fixed?