github-112233 / 4dheartmodel

Framework to enable the inference of a high resolution personalized 4D (3D plus time) surface mesh of the cardiac structures from 2D echocardiography video data.

Weakly supervised inference of personalized heart meshes based on echocardiography videos

This is the official repository of the paper: "Weakly supervised inference of personalized heart meshes based on echocardiography videos."

Requirements

This code is tested on Tensorflow 2.7. Requirements (including tensorflow) can be installed using:

pip install -r requirements.txt

Remark: psbody-mesh (MPI-IS/mesh) has to be installed separately. Install mesh processing libraries from MPI-IS/mesh.

Data

Download the publicly available echocardiography videos from https://echonet.github.io/dynamic/. (The data folder can be specified as argument when running the training script.)

Running the code

The following python scripts need to be executed one after the other:

1. Train the echo autoencoder (EA) with:

python run_generative_heart_model.py source/configs/generative_model --mode=dhb_eae  --echo_dir=<path_to_echonet_data_folder>

The run is saved under the experiments/EAE/

2. Train the mesh video autoencoder (MVA) with:

python run_generative_heart_model.py source/configs/generative_model --mode=dhb_mae  --echo_dir=<path_to_echonet_data_folder>

The run is saved under the experiments/MAE/

Note that the training of the mesh video autoencoder takes up to two to three days. Only if the phase scatter plot located in the experiments/MAE//plots/test/phases/ folder shows a nice correlation, one should continue with the next step.

3. (OPTIONAL) Train the echo EF predictor:

This run is to have a sanity check for the latent vectors of the echo autoencoder. The predicted EF (under plots) should have fairly good correlation with the ground-truth.

python run_generative_heart_model.py source/configs/generative_model --mode=echo_ef_pred  --echo_dir=<path_to_echonet_data_folder>

The run is saved under the experiments/ECHO_EF/

4. Train the mesh EF predictor:

python run_generative_heart_model.py source/configs/generative_model --mode=mesh_ef_pred --echo_dir=<path_to_echonet_data_folder>

The run is saved under the experiments/MESH_EF/

5. Train the cycle GAN:

python run_generative_heart_model.py source/configs/generative_model --mode=gm --echo_dir=<path_to_echonet_data_folder>

The run is saved under the experiments/GenModel/

Under "visualization" different reconstructed 4D heart shapes are generated.

Under "ef_data" one can find the ejection fraction (EF) correlation plots between doctor derived EF from the original echos and the derived EF from the predicted 4D meshes.

• EF_Biplane_scatter: Echo EF vs. EF from the predicted mesh calculated with biplane
• EF_Vol_scatter: Echo EF vs. EF from predicted mesh calculated from the volumes directly
• EF_Mesh_scatter: EF from predicted mesh calculated with biplane vs. EF predictions from mesh latents
• EF_Pred_scatter: Echo EF vs. EF predictions from mesh latents

---

If this repository was helpful for your research please consider citing:

@article{laumer2022weakly, title={Weakly supervised inference of personalized heart meshes based on echocardiography videos}, author={Laumer, Fabian and Amrani, Mounir and Manduchi, Laura and Beuret, Ami and Rubi, Lena and Dubatovka, Alina and Matter, Christian M and Buhmann, Joachim M}, journal={Medical Image Analysis}, pages={102653}, year={2022}, publisher={Elsevier} }