Comments (5)
At the rheobase (Ipulse = -1.90 pA or - in relation to the -12 pA holding current - at 10.10 pA) the delay to first spike becomes ~2700 ms (not shown here; can be tuned to even longer delays with a more detailed value for the rheobase).
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@jrieke @borismarin : Analyzing delays in this model a bit more can be rewarding. There's an argument in the literature that Kf (Shal) channels are singlehandedly responsible for creating delays in these neurons (cf. papers by Carsten Duch et al), but as you can see in this model, we can get delays (almost) without Kf. I think a paper can be written to show to experimentalists that Kf is not the only mechanism to generate delays and also explain why the experiments may be reaching the wrong conclusion. If you guys can really pinpoint the dynamical mechanism resulting in delays, we can make a strong argument. Let me know if you're interested to explore in this direction.
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Sounds good @borismarin ! I'd be happy to put together the literature support for my argument. Please remind me when it's closet to when you guys get together.
from drosophila-dynamics.
@cengique Sounds very interesting - I will put it into the list of ideas in our Google doc. Looking forward to discuss this!
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Related Issues (12)
- Raise f-I curve HOT 19
- Make some plots of trajectories in phase space HOT 5
- Make 2 parameter continuation for all conductances (gleak, gKs, ...) HOT 3
- Investigate delays HOT 7
- Find rheobase HOT 7
- Investigate spike amplitudes HOT 1
- Investigate excitability in reaction to short square current pulses HOT 4
- Should this fork go on a branch rather than being on master? HOT 2
- Make some nice plots of voltage traces HOT 5
- Find power laws for plots HOT 7
- Extend analysis and plots to > 55 pA to show effect of Hopf bifurcation
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