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Home Page: https://modeldb.science/151949
DRt neuron model (Sousa et al., 2014)
Home Page: https://modeldb.science/151949
These are the NEURON files for modelling a tonic neuron from the Dorsal Reticular Nucleus (DRt), based on the experimental voltage traces. This model was used for: 1) recreating the firing properties of DRt neurons; 2) studying the possible membrane currents giving rise to the after-hyperpolarization variability observed experimentally; 3) exploring the mechanisms shaping the membrane potential histograms under spontaneous activity conditions. The Hodgkin-Huxley formalism was used to describe the ionic currents present in the model: a persistent sodium current (INa), a delayed-rectifier potassium current (IKdr), a voltage dependent calcium current (ICa, L-type high threshold), and a calcium activated potassium current (IK,Ca, or IAHP given its role in shaping the after-hyperpolarization). The model also included a description for the internal calcium concentration dynamics. Synapses were modelled using dual exponential conductance profiles and were introduced for the sole purpose of introducing and analysing the contribution of membrane fluctuations. The parametrization of the synaptic inputs was set in order to produce a zero net change in membrane potential. Stochastic network activity was simulated by adding random excitatory and inhibitory synaptic inputs with predefined mean times. Membrane potential fluctuations were generated by injecting normally distributed current noise to the neuron model. This model is described in: Sousa M., Szucs P, Lima D. and Aguiar P. "The pronociceptive dorsal reticular nucleus contains mostly tonic neurons and shows a high prevalence of spontaneous activity in block preparation". Accepted at Journal of Neurophysiology, January 2014. Core model parameters are specified in the Appendix section. Authors: Mafalda Sousa and Paulo Aguiar contact email: [email protected] and [email protected]
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