naklama / hormonelevels

Compute and graph hormone levels for transgender HRT

HormoneLevels

Compute and graph hormone levels for transgender HRT

Current state of development

Since I'm developing this software's features as I need them, it is currently only for transfeminine HRT. It can graph the amount of estradiol valerate inside the body, and using that, and the lab results at certain points, a conversion factor to calculate the blood levels from the amount of the ester in the body is calculated, by taking the average of the ratio between lab tests and calculated hormone in the body.

The confidence interval is calculated taking the square sum residuals between the resulting blood level curve, and the actual lab tests, and calculating the standard deviation.

Planned features

• Graphing of long term fitting with known labs to detect shifts in metabolism
  • Ways to adjust for these
• Different HRT options
  • Different Estradiol Esters
  • Testosterone Esters
  • Different methods of delivery

Implemented features

• Calculate and plot blood level estimations from known levels at certain points
• Rough model for gels like Gynokadin and Estrogel

Contributing

I'd love for some transmasculine folk to get in touch with me, and provide me with the names and half-lifes of commonly used testosterone esters, so I can add them to the project. You can also add them as an issue as an easy way to ask for certain hormone esters to be added.

Of course, feel free to create the files for that yourself, and make a pull-request. I'd be happy to collaborate with someone implementing some cool additional features.

Any papers going into detail about the pharmacokinetics of various esters that may be of interest would be greatly appreciated, to bring the modelling as close to the real thing as possible.

Disclaimer

I am not a medical professional. The values estimated from this software should not be used to make medical decisions, without verification by actual blood tests. I did however study chemistry, have a good knowledge and experience in pharmakinetics, and software modelling. This software is intended to give you a better feeling of where your hormone levels probably are, and is not intended to replace blood tests. In fact, it relies on blood tests to improve its estimations.