Data and supporting files for: "Order and disorder โ an integrative structure of the full-length human growth hormone receptor" by Kassem, Araya-Secchi et al.
Include here are:
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The input and start files for the reported modeling and simulations of: hGHR-ICD and hGHRfl-GFP.
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Input files and models obtained for GHR-ECD (Rosetta Floppy-Tail), GHR-ECD-TMD (Rosetta Domain-Assembly).
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Scripts used in the analysis of simulation data and SAXS Fits.
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Fits between the SAXS data and theoretical scattering from structures of GHR-ECD, GHR-ICD and GHRfl-GFP obtained from modeling and simulations as reported in the manuscript.
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Simulation trajectories are avaliable at:https://doi.org/10.5281/zenodo.4737501
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Models of GHR-ECD and GHR-ECD+TMD, backmapped structures from CG simulations (GHR-ICD and GHRfl-GFP) and WillItFit SAXS Fits for hGHRfl-GFP avaliable at:https://doi.org/10.5281/zenodo.4740700