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  • aheze / popovers

    present, A library to present popovers. Simple, modern, and highly customizable. Not boring!

    From user aheze

  • beckschen / transunet

    present, This repository includes the official project of TransUNet, presented in our paper: TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation.

    From user beckschen

  • carsonxyz / cnppopupcontroller

    present, *DEPRECATED* CNPPopupController is a simple and versatile class for presenting a custom popup in a variety of fashions. It includes a many options for controlling how your popup appears and behaves.

    From user carsonxyz

  • facebookresearch / denoiser

    present, Real Time Speech Enhancement in the Waveform Domain (Interspeech 2020)We provide a PyTorch implementation of the paper Real Time Speech Enhancement in the Waveform Domain. In which, we present a causal speech enhancement model working on the raw waveform that runs in real-time on a laptop CPU. The proposed model is based on an encoder-decoder architecture with skip-connections. It is optimized on both time and frequency domains, using multiple loss functions. Empirical evidence shows that it is capable of removing various kinds of background noise including stationary and non-stationary noises, as well as room reverb. Additionally, we suggest a set of data augmentation techniques applied directly on the raw waveform which further improve model performance and its generalization abilities.

    From organization facebookresearch

  • leonatan / lnpopupcontroller

    present, A framework for presenting view controllers as popups of other view controllers, much like the Apple Music and Podcasts apps.

    From user leonatan

  • microsoft / malmo

    present, Project Malmo is a platform for Artificial Intelligence experimentation and research built on top of Minecraft. We aim to inspire a new generation of research into challenging new problems presented by this unique environment. --- For installation instructions, scroll down to *Getting Started* below, or visit the project page for more information:

    From organization microsoft

    Home Page: https://www.microsoft.com/en-us/research/project/project-malmo/

  • naalytics / assemblies-of-putative-sars-cov2-spike-encoding-mrna-sequences-for-vaccines-bnt-162b2-and-mrna-1273

    present, RNA vaccines have become a key tool in moving forward through the challenges raised both in the current pandemic and in numerous other public health and medical challenges. With the rollout of vaccines for COVID-19, these synthetic mRNAs have become broadly distributed RNA species in numerous human populations. Despite their ubiquity, sequences are not always available for such RNAs. Standard methods facilitate such sequencing. In this note, we provide experimental sequence information for the RNA components of the initial Moderna (https://pubmed.ncbi.nlm.nih.gov/32756549/) and Pfizer/BioNTech (https://pubmed.ncbi.nlm.nih.gov/33301246/) COVID-19 vaccines, allowing a working assembly of the former and a confirmation of previously reported sequence information for the latter RNA. Sharing of sequence information for broadly used therapeutics has the benefit of allowing any researchers or clinicians using sequencing approaches to rapidly identify such sequences as therapeutic-derived rather than host or infectious in origin. For this work, RNAs were obtained as discards from the small portions of vaccine doses that remained in vials after immunization; such portions would have been required to be otherwise discarded and were analyzed under FDA authorization for research use. To obtain the small amounts of RNA needed for characterization, vaccine remnants were phenol-chloroform extracted using TRIzol Reagent (Invitrogen), with intactness assessed by Agilent 2100 Bioanalyzer before and after extraction. Although our analysis mainly focused on RNAs obtained as soon as possible following discard, we also analyzed samples which had been refrigerated (~4 ℃) for up to 42 days with and without the addition of EDTA. Interestingly a substantial fraction of the RNA remained intact in these preparations. We note that the formulation of the vaccines includes numerous key chemical components which are quite possibly unstable under these conditions-- so these data certainly do not suggest that the vaccine as a biological agent is stable. But it is of interest that chemical stability of RNA itself is not sufficient to preclude eventual development of vaccines with a much less involved cold-chain storage and transportation. For further analysis, the initial RNAs were fragmented by heating to 94℃, primed with a random hexamer-tailed adaptor, amplified through a template-switch protocol (Takara SMARTerer Stranded RNA-seq kit), and sequenced using a MiSeq instrument (Illumina) with paired end 78-per end sequencing. As a reference material in specific assays, we included RNA of known concentration and sequence (from bacteriophage MS2). From these data, we obtained partial information on strandedness and a set of segments that could be used for assembly. This was particularly useful for the Moderna vaccine, for which the original vaccine RNA sequence was not available at the time our study was carried out. Contigs encoding full-length spikes were assembled from the Moderna and Pfizer datasets. The Pfizer/BioNTech data [Figure 1] verified the reported sequence for that vaccine (https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/), while the Moderna sequence [Figure 2] could not be checked against a published reference. RNA preparations lacking dsRNA are desirable in generating vaccine formulations as these will minimize an otherwise dramatic biological (and nonspecific) response that vertebrates have to double stranded character in RNA (https://www.nature.com/articles/nrd.2017.243). In the sequence data that we analyzed, we found that the vast majority of reads were from the expected sense strand. In addition, the minority of antisense reads appeared different from sense reads in lacking the characteristic extensions expected from the template switching protocol. Examining only the reads with an evident template switch (as an indicator for strand-of-origin), we observed that both vaccines overwhelmingly yielded sense reads (>99.99%). Independent sequencing assays and other experimental measurements are ongoing and will be needed to determine whether this template-switched sense read fraction in the SmarterSeq protocol indeed represents the actual dsRNA content in the original material. This work provides an initial assessment of two RNAs that are now a part of the human ecosystem and that are likely to appear in numerous other high throughput RNA-seq studies in which a fraction of the individuals may have previously been vaccinated. ProtoAcknowledgements: Thanks to our colleagues for help and suggestions (Nimit Jain, Emily Greenwald, Lamia Wahba, William Wang, Amisha Kumar, Sameer Sundrani, David Lipman, Bijoyita Roy). Figure 1: Spike-encoding contig assembled from BioNTech/Pfizer BNT-162b2 vaccine. Although the full coding region is included, the nature of the methodology used for sequencing and assembly is such that the assembled contig could lack some sequence from the ends of the RNA. Within the assembled sequence, this hypothetical sequence shows a perfect match to the corresponding sequence from documents available online derived from manufacturer communications with the World Health Organization [as reported by https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/]. The 5’ end for the assembly matches the start site noted in these documents, while the read-based assembly lacks an interrupted polyA tail (A30(GCATATGACT)A70) that is expected to be present in the mRNA.

    From user naalytics

  • pkluz / pkrevealcontroller

    present, PKRevealController is a delightful view controller container for iOS, enabling you to present multiple controllers on top of one another.

    From user pkluz

  • snail-z / zhpopupcontroller

    present, Help you pop up custom views easily. and support pop-up animation, layout position, mask effect and gesture interaction etc.

    From user snail-z

  • soarcn / bottomsheet

    present, One way to present a set of actions to a user is with bottom sheets, a sheet of paper that slides up from the bottom edge of the screen. Bottom sheets offer flexibility in the display of clear and simple actions that do not need explanation.

    From user soarcn

    Home Page: http://soarcn.github.io/BottomSheet

  • trustedsec / unicorn

    present, Unicorn is a simple tool for using a PowerShell downgrade attack and inject shellcode straight into memory. Based on Matthew Graeber's powershell attacks and the powershell bypass technique presented by David Kennedy (TrustedSec) and Josh Kelly at Defcon 18.

    From organization trustedsec

    Home Page: https://www.trustedsec.com

  • winmerge / winmerge

    present, WinMerge is an Open Source differencing and merging tool for Windows. WinMerge can compare both folders and files, presenting differences in a visual text format that is easy to understand and handle.

    From organization winmerge

    Home Page: https://winmerge.org/

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