Os dois principais bancos de dados públicos primários, GenBank-NCBI e EMBL-ENA con- têm a Sequência de genes, proteínas e genomas completos atualizadas periodicamente (entre 2 a 3 meses), porém pouco trabalho manualmente é realizado nesses bancos. No entanto, seções especiais podem ser encontradas tanto no NCBI como no EMBL, as quais contêm ferramentas ou dados de Sequências analisados e classificados de grande utilidade para a pesquisa. Assim, esses dois principais bancos de dados podem ser utilizados como páginas líderes para qualquer pesquisa envolvendo dados biológicos.
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