structuralgenomicsconsortium / cnp10-chikv-naphthoquinone Goto Github PK
View Code? Open in Web Editor NEWAn Open Chemistry Network dedicated to finding hits vs CHIKV based on a hit containing an naphthoquinone.
An Open Chemistry Network dedicated to finding hits vs CHIKV based on a hit containing an naphthoquinone.
It has been raised some concern regarding the structural similarity of these naphthoquinones to RA-0001914 - from DENV Rdrp ChEMBL series. RA-0001914 showed cytotoxicity when tested for human mitochondrial RNA production.
The naphthoquinones report show no cytotoxicity when tested in the following conditions: Quote from the paper "The naphthoquinone derivatives cytotoxicity in Vero cells was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide tetrazolium (MTT) reduction colorimetric assay in 96-well plate and incubated for 24 h at 37 °C.28 After, naphthoquinones derivatives were added in increasing concentrations, ranging from 50 to 1000 µM, diluted in DMEM. After this period, the cells were incubated with the MTT method and evaluated in a microplate reader to determine cell viability. DMSO-treated cells (1.0%) in DMEM were used as control of the evaluation. Determination of cell viability was calculated by percentage comparing treated cells with untreated cells and cells in DMSO" 10.21577/0103-5053.20220010.
It is important that cytotoxicity is evaluated alongside antiviral activity.
A declarative, efficient, and flexible JavaScript library for building user interfaces.
🖖 Vue.js is a progressive, incrementally-adoptable JavaScript framework for building UI on the web.
TypeScript is a superset of JavaScript that compiles to clean JavaScript output.
An Open Source Machine Learning Framework for Everyone
The Web framework for perfectionists with deadlines.
A PHP framework for web artisans
Bring data to life with SVG, Canvas and HTML. 📊📈🎉
JavaScript (JS) is a lightweight interpreted programming language with first-class functions.
Some thing interesting about web. New door for the world.
A server is a program made to process requests and deliver data to clients.
Machine learning is a way of modeling and interpreting data that allows a piece of software to respond intelligently.
Some thing interesting about visualization, use data art
Some thing interesting about game, make everyone happy.
We are working to build community through open source technology. NB: members must have two-factor auth.
Open source projects and samples from Microsoft.
Google ❤️ Open Source for everyone.
Alibaba Open Source for everyone
Data-Driven Documents codes.
China tencent open source team.