structuralgenomicsconsortium / cnp17-denvrdrp-enaminecovalent

An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on exploring the Enamine covalent library

CNP17-DENVRdrp-EnamineCovalent

An SGC Open Chemical Networks Project (number 17) devoted to the DENV Rdrp, focusing specifically on identifying a possible hit in a covalent enamine library.

• For the science background, head to the Wiki page to check out the living paper that is being written there.

Are you answering our call?

Please go to issues for more details

General information

You contribute synthetic chemistry and in return the SGC offers biology. Together we can generate tool compounds to understand biology and validate drug targets to help cure disease. Everything is open, with all content governed by a CC-BY-4.0 licence. If this sounds interesting, and you agree to the simple RULES, you can get started.

For answers to all the questions you have, go to the FAQs.

If you'd like to contact someone to talk about contributing, then write something in an Issue (see the tab above), which is a good way to communicate openly. (Issues describe what currently needs doing and act as a discussion forum - you need a Github account but it's super easy and not spammy. There's also an email address ([email protected]) you can use to ask questions. You can read more about all this in the "How To" Area

Some of people involved in this CNP:
Professor Matthew Todd, University College London, Head of Chemistry Networks at the SGC - @mattodd
Professor Tim Willson, University of North Carolina Chapel Hill - @tmw20653
Dr Rebecka Isaksson, Univeristy College London, chemistry lead - @RebeckaIsaksson
Dr Peter Brown, University North Carolina Chapel Hill, project manager
Dr Tina Leisner, University North Carolina Chapel Hill, biological testing (protein inhibition)
Dr Jessica Smith, Oregon Health & Science University, biological testing (antiviral assay)
Dr Anwar Hossain, University North Carolina Chapel Hill, compound managment - @ahsgc

Pharma Champion: Vacant.
The Sir James Murray Student Champion: vacant

Other Contributors To Date:

Potential Contributors:

You can see other contributors in the Issues (tab above).

The licence for the content of this project is, unless otherwise stated, and as for all OCN projects, CC-BY-4.0. This means you can do whatever you like with the project content, including making money, provided you cite the project.

This project is part of the SGC's Open Chemistry Networks initiative.

cnp17-denvrdrp-enaminecovalent's Issues

Join this project!

Hi,

If you've made it this far you are clearly keen on getting involved in this project, and we are glad for your interest!

In the Wiki you can learn more about what has been done in the project; the sidebar on the right holds pages with more details on the various explorations.

We have identified these sulfonyl-fluoride compounds as being favored in binding DENV2 over other viruses we have tested.

We want to find collaborators that can join us in exploring these covalent ligands - do you have any sulfonyl-fluoride compounds, preferably bound to aromatic heterocycles? Get in touch with us, and we will test them.