2502-3: Iron saturation [Mass Fraction] in Serum or Plasma about loinc2hpoannotation

[kingmanzhang]

I think the biology is different but the annotation is probably fine. Iron is transported by transferrin, so low saturation roughly means low serum iron (?).

https://emedicine.medscape.com/article/2087960-overview

[callahantiff]

I think my initial question was not worded clearly, sorry about that.

What I meant to ask was why increased and decreased iron saturation (2502-3) lab results were being annotated to HPO terms that measured iron serum? I am asking this because there are HPO terms (HP:0012464 and HP:0012463) that measure increased and decreased iron or transferrin saturation?

Annotating this LOINC lab to the saturation HPO terms rather than the serum HPO terms seems like a more accurate mapping. Or was there a specific reason why you did not annotate it to those terms?

[kingmanzhang]

In this case, annotating to your suggest HPO terms sounds more precise. I will relay this to @LCCarmody to see if she agrees. It is possible that your suggested classes are new.

[callahantiff]

Thanks Aaron, that sounds great. I'm wondering if I should add the dates that HPO terms were added when posting issues, but only if that would be helpful.