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LLM Cancer Target

基于大模型搭建文献信息提取器,从文献摘要中提出癌症潜在靶点。

癌症靶点的挖掘,特别是针对特定亚群病人的靶点(比如有着 TP53 突变的癌细胞的依赖性基因或通路是什么)的发现对癌症精准治疗有着关键的作用。基于 ChatGPT 或类似的大语言模型可以方便的从文献中提取这样的信息,通过整合这些靶点信息,有利于后续的实验验证以及进一步的数据挖掘。

该 Demo 通过对 ChatGPT 进行 Few-shot promoting (提供了两个正例,一个负例样本,具体见 app.pyget_response 函数),使其可以进行癌症依赖性信息提取。后续可以进一步让模型输出 JSON 格式,并对 PubMed 上的文献摘要进行爬取,生成大量的 “癌症--基因/通路” 依赖性关系。

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