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scBSP is a specialized package designed for processing biological data, specifically in the analysis of gene expression and cell coordinates. It efficiently computes p-values for a given set of genes based on input matrices representing cell coordinates and gene expression data.

License: GNU General Public License v3.0

Python 96.05% Makefile 3.95%

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scbsp's Issues

scBSP not compatible with Visium HD data (single-cell resolution of ST data) - Memory Error

Hey, I'm trying to run scBSP and it gives a memory error (actually, it simply kills the terminal) using Visium HD data (600k bins/spots)

>>> p_values = scbsp.granp(input_sp_mat, input_exp_mat_raw, d1, d2)
Killed

Adata shape:

AnnData object with n_obs ร— n_vars = 605471 ร— 18085
obs: 'in_tissue', 'array_row', 'array_col'
var: 'gene_ids', 'feature_types', 'genome'
uns: 'spatial'
obsm: 'spatial'

Unfortunately, it doesn't seem to be compatible with high resolution spatial data

Thanks

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