jessemzhang / tn_test Goto Github PK
View Code? Open in Web Editor NEWpost-clustering differential expression test
post-clustering differential expression test
Hi there!
I've been playing around with tn_test
in some of my work, and have been appreciating its approach for identifying cluster markers. I've been wanting to integrate it with Scanpy's scanpy.tl.rank_genes_groups()
functionality, and was just wondering if there was a simple way to retrieve the test statistic?
Best,
Dakota
Hello,
First of all, thank you for publishing a paper on this method because I have felt that the pvalues of scRNA-seq just do not sit well with me and I have felt it produces a lot of false discoveries.
I just brought up this method/your paper to the attention of our informatics group, who are very interested in testing it, but one of the senior informatician had brought up a very valid point in that many of the scRNA-seq sets we deal with do not have normal distributions within each cluster and we may see bimodal or exponential distributions in our datasets. This is especially the case in our immunology data sets and dealing with rare cells.
Any ideas or suggestions would be appreciated! Thank you!
A declarative, efficient, and flexible JavaScript library for building user interfaces.
๐ Vue.js is a progressive, incrementally-adoptable JavaScript framework for building UI on the web.
TypeScript is a superset of JavaScript that compiles to clean JavaScript output.
An Open Source Machine Learning Framework for Everyone
The Web framework for perfectionists with deadlines.
A PHP framework for web artisans
Bring data to life with SVG, Canvas and HTML. ๐๐๐
JavaScript (JS) is a lightweight interpreted programming language with first-class functions.
Some thing interesting about web. New door for the world.
A server is a program made to process requests and deliver data to clients.
Machine learning is a way of modeling and interpreting data that allows a piece of software to respond intelligently.
Some thing interesting about visualization, use data art
Some thing interesting about game, make everyone happy.
We are working to build community through open source technology. NB: members must have two-factor auth.
Open source projects and samples from Microsoft.
Google โค๏ธ Open Source for everyone.
Alibaba Open Source for everyone
Data-Driven Documents codes.
China tencent open source team.